RESEARCH & ACADEMIC INTEREST
Cancer is a collection of diseases hallmarked by uncontrolled cell division. Cancer treatment involves varying combinations of surgery, radiation, chemotherapy and hormone therapy. Chemotherapy employs the use of drugs that kill the rapidly dividing cells (characteristic of cancer cells). For more than 50 years, various drugs have been used to treat cancer. However, scientists are still in search of novel anti-cancer compounds because cancer becomes resistant to existing drugs. My research focus is to identify novel anti-cancer agents by screening newly constructed compounds. The initial screen identifies compounds with capability of interfering with cell division and the select compounds are investigated for the mechanism of cell death and identifying molecular target.
Sunil Kumar, Ranjana Aggarwal, Virendar Kumar, Rachna Sadana, Bhumi Patel, Pawan Kaushik and Dhirender Kaushik. Solvent-free synthesis of bacillamide analogues as novel cytotoxic and anti-inflammatory agents. European Journal of Medicinal Chemistry, 123, (2016), 718-726.
Mamta, Ranjana Aggarwal, Jessie Smith, and Rachna Sadana. Synthesis and cytotoxic evaluation of some new 1-(6-chloropyridazine-3-yl)-2-H/Alyl-4 phenyl-1H-pyrazol-5-amines and their derivatives. Indian Journal of Heterocyclic Chemistry, Nov 2016, (Accepted).
Venkataramana Reddy P. O., Mukund P. Tantak, Reyna Valdez, Rajnish Prakah Singh, Rachna Sadana, Okram M Singh and Dalip Kumar. Synthesis and biological Evaluation of novel carbazolyl glyoxamides as Anti-cancer and Anti-bacterial Agents. RSC Advances, 2016, 6, 9379-9386.
Buchi Vaddula, Mukund P. Tantak, Rachna Sadana, Michael Gonzales and Dalip Kumar. One Pot Synthesis and in-vitro anticancer evaluation of 5-(2'-indolyl)thiazoles. Scientific reports, 2016, Article number 23401. DOI: 10.1038/srep23401
Cameron S. Brand, Rachna Sadana, Sundeep Malik, Alan V. Smrcka, and Carmen W. Dessauer. Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform Specific Use of Multiple Interactions. Molecular Pharmacology, 2015, 88 (4), 758-764.
- Welkin H. Pope, Charles A. Bowman, Daniel A. Russell, Deborah Jacobs-Sera1, David J. Asai, Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES), Phage Hunters Integrating Research and Education (PHIRE) PHIRE, Mycobacterial Genetics Course (MGC), Steven G. Cresawn, William R. Jacobs Jr., Roger W. Hendrix1, Jeffrey G. Lawrence1, and Graham F. Hatfull. Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of 11 phage genetic diversity. Elife, 2015, 28, 4:e06416. doi: 10.7554/eLife.06416.
- Multiple UHD freshmen students and faculty (Rachna Sadana, Phyllis Griffard and Akif Uzman) are listed as co-authors in the supplemental information).
Aggarwal R, Rani C, Sadana R, Busari K, Sharma C, and Aneja KR. Hypervalent iodine mediated synthesis of some new N-(4,6-dimethylpyrimidin-2-yl) N′-(4-arylthiazol-2-yl)hydrazines and their evaluation as antibacterial and cytotoxic agents. Chemistry and Biology Interface, 2013, Vol 3, 389-397.
Dessauer CW and Sadana R. Adenylyl cyclases. Encyclopedia of signaling molecules, 2012, part 2, 59-66.
2015 Excellence in Teaching Award