Research and Academic Interest
How macromolecular molecules are moved about in living systems continues to fascinate me. As do the products microbes manufacture for survival, whether that be caustic molecules or antibiotic production to gain a growth advantage over the competition, or the enzymatic products used to catabolize molecules into smaller units that are either oxidized to release energy, or used in other anabolic reactions.
As a professor, my focus remains teaching, mentoring, and guiding students through the labyrinth of their science education. I've had the luck to have many amazing mentors and professors who have cajoled, tutored, and nudged me to this point in my own career. I'm guided by much of what I've learned from so many. The professors I found most effective were those that made me want to do well, inspired me to do well, and had more belief in my abilities than I did. And they were right. Their mission is now my vocation.
Whitaker, N., Y. Chen, S. J. Jakubowski, M. Sarkar, F. Li, and P. J. Christie. 2015. The All-Alpha Domains of Agrobacterium tumefaciens and Enterococcus faecalis PCF10-encoded Type IV Secretion Systems Confer Specificity of Binding of Cognate DNA Substrates. J. Bacteriol. JB 00189-15.
Sarkar, M. K., S. I. Husnain, S. J. Jakubowski, and P.J Christie. 2013. Isolation of Bacteriol Type IV Machine Subassemblies. Methods Mol Biol. 2013;966:187-204. Doi: 10.1007/978-1-62703-245-2_12.
Jakubowski, S. J., J. E. Kerr, I. Garza, V. Krishnamoorthy, R. Bayliss, G. Waksman, and P. J. Christie. 2009. Agrobacterium VirB10, domain requirements for type IV secretion and T pilus biogenesis. Mol. Microbiol. 71(3):779-794.
Jakubowski, S. J., E. Cascales, V. Krishnamoorthy, and P. J. Christie. 2005. Agrobacterium tumefaciens VirB9, an outer membrane-associated component of a type IV secretion system, regulates substrate selection and T-pilus biogenesis. J. Bacteriol. 187(10):3486-95.
Cascales, E., K. Atmakuri, V. Krishnamoorthy, S. J. Jakubowski, and P. J. Christie. 2005. Biogenesis, Architecture, and Function of Type IV Secretion Systems. ARM. 59:451-485.
Jakubowski, S. J., V. Krishnamoorthy, E. Cascales, and P. J. Christie. 2004. Agrobacterium tumefaciens VirB6 domains direct the ordered export of a DNA substrate through a type IV secretion system. J. Mol. Biol. 341:961-977.
Jakubowski, S. J., V. Krishnamoorthy, and P. J. Christie. 2003. Agrobacterium tumefaciens VirB6 protein participates in formation of VirB7 and VirB9 complexes required for type IV secretion. J. Bacteriol. 185(9):2867-78.
Ding, Z., Z. Zhao, S. J. Jakubowski, A. Krishnamohan, W. Margolin, and P. J. Christie. 2002. A novel cytology-based, two-hybrid screen for bacteria applied to protein-protein interaction studies of a type IV secretion system. J. Bacteriol. 184(20):5572-82.
Sagulenko, V., E. Sagulenko, S. J. Jakubowski, E. Spudich, and P. J. Christie. 2001. VirB7 lipoprotein is exocellular and associates with the Agrobacterium tumefaciens T pilus. J. Bacteriol. 183(12):3642-51.
2016 UHD Outstanding Adjunct Teaching Award